Onset of Type 1 Diabetes

Advances in the Delayed-Onset of Type 1 Diabetes:

Strategies to Improve Awareness and Care for the Practicing Clinician

Guidelines and Practice Parameters
Resource

Resource Address
American Diabetes Association Professional Practice Committee.2. Diagnosis and classification of diabetes: Standards of care in diabetes-2024.Diabetes Care.2024;47(suppl 1):S20-S42. https://diabetesjournals.org/care/article/47/Supplement1/S20/153954
American Diabetes Association Professional Practice Committee.3. Prevention or delay of diabetes and associated comorbidities: Standards of care in diabetes-2024.Diabetes Care.2024;47(suppl 1):S43-S51. https://diabetesjournals.org/care/article/47/Supplement1/S43/153945
Besser REJ,Bell KJ,Couper JJ,et al.ISPAD Clinical Practice Consensus Guidelines 2022:Stages of type 1 diabetes in children and adolescents.Pediatr Diabetes.2022;23:1175-1187. https://cdn.ymaws.com/www.ispad.org/resource/resmgr/consensus guidelines 2018/guidelines2022/ch.2pediatric diabetes-2.pdf
Mehta S,Ryabets-Lienhard A,Patel N,et al.Pediatric Endocrine Society statement on considerations for the use of teplizumab in clinical practice.Horm Res Paediatr.2024;Apr 30:1-12. https://pubmed.ncbi.nlm.nih.gov/38663372/
Philip M,Achenbach P,Addala A,et al.Consensus guidance for monitoring individuals with islet autoantibody-positive pre-stage 3 type 1 diabetes.Diabetes Care.2024;Jun 24:dci240042. https://pubmed.ncbi.nlm.nih.gov/38912694/

References/Reading List
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Resource Address
Atkinson MA, Mirmira RG. The pathogenic "symphony" in type 1 diabetes: A disorder of the immune system,β cells,and exocrine pancreas. Cell Metab.2023;35:1500-1518. https://pubmed.ncbi.nlm.nih.gov/37478842/
Bogun MM,Bundy BN,Goland RS,Greenbaum CJ.C-peptide levels in subjects followed longitudinally before and after type 1 diabetes diagnosis in TrialNet.Diabetes Care.2020;43:1836-1842. https://pubmed.ncbi.nlm.nih.gov/32457058/
Fyvie MJ,Gillespie KM.The importance of biomarker development for monitoring type 1 diabetes progression rate and therapeutic responsiveness.Front Immunol.2023;14:1158278. https://pubmed.ncbi.nlm.nih.gov/37256143/
Herold KC,Bundy BN,Long SA,et al.An anti-CD3 antibody,teplizumab,in relatives at risk for type 1 diabetes.N Engl J Med.2019;381:603-613. https://pubmed.ncbi.nlm.nih.gov/31180194/
Herold KC,Gitelman SE,Gottlieb PA,et al.Teplizumab:A disease-modifying therapy for type 1 diabetes that preserves β-Cell function.Diabetes Care.2023;46:1848-1856. https://pubmed.ncbi.nlm.nih.gov/37607392/

Holt RIG, DeVries JH, Hess-Fischl A, et al. The management of type 1 diabetes in adults. A consensus report by the American Diabetes Association (ADA) and the European Association for the Study of Diabetes(EASD).Diabetes Care.2021;44:2589-2625. https://pubmed.ncbi.nlm.nih.gov/34593612/
Insel RA,Dunne JL,Atkinson MA,et al. Staging presymptomatic type 1 diabetes:A scientific statement of JDRF,the Endocrine Society,and the American Diabetes Association.Diabetes Care.2015;38:1964-1974. https://pubmed.ncbi.nlm.nih.gov/26404926/
Katsarou A,Gudbjörnsdottir S,Rawshani A,et al.Type 1 diabetes mellitus.Nat Rev Dis Primers.2017;3:17016. https://pubmed.ncbi.nlm.nih.gov/28358037/
Leslie RD,Evans-Molina C,Freund-Brown J,et al.Adultonset type 1 diabetes:Current understanding and challenges.Diabetes Care.2021;44:2449-2456. https://pubmed.ncbi.nlm.nih.gov/34670785/
Linsley PS,Greenbaum CJ,Nepom GT.Uncovering pathways to personalized therapies in type 1 diabetes.Diabetes.2021;70:831-841. https://pubmed.ncbi.nlm.nih.gov/33741606/
O'Donnell HK,Rasmussen CG,Dong F,et al.Anxiety and risk perception in parents of children identified by population screening as high risk for type 1 diabetes.Diabetes Care.2023;46:2155-2161. https://pubmed.ncbi.nlm.nih.gov/37673098/
Ospelt E,Hardison H,Rioles N,et al.Understanding providers'readiness and attitudes toward autoantibody screening:A mixed-methods study.Clin Diabetes.2024;42:17-26. https://pubmed.ncbi.nlm.nih.gov/38230325/
Ramos EL,Dayan CM,Chatenoud L,et al.Teplizumab andβ-Cell function in newly diagnosed type 1 diabetes.N Engl J Med.2023;389:2151-2161. https://pubmed.ncbi.nlm.nih.gov/37861217/
Simmons KM,Sims EK.Screening and prevention of type1 diabetes:Where are we?J Clin Endocrinol Metab.2023;108:3067-3079. https://pubmed.ncbi.nlm.nih.gov/37290044/
Simmons KMW,Frohnert BI,O'Donnell HK,et al.Historical insights and current perspectives on the diagnosis and management of presymptomatic type 1 diabetes.Diabetes Technol Ther.2023;25:790-799. https://pubmed.ncbi.nlm.nih.gov/37695674/
Sims EK,Besser REJ,Dayan C,et al.Screening for type1 diabetes in the general population:A status report and perspective.Diabetes.2022;71:610-623. https://pubmed.ncbi.nlm.nih.gov/35316839/
Sims EK,Bundy BN,Stier K,et al.Teplizumab improves and stabilizes beta cell function in antibody-positive high-risk individuals.Sci Transl Med.2021;13:aebc8980. https://pubmed.ncbi.nlm.nih.gov/33658358/
Smigoc Schweiger D.Recent advances in immune-based therapies for type1 diabetes.Horm Res Paediatr.2023;96:631-645. https://pubmed.ncbi.nlm.nih.gov/35533645/
VanBuecken D,Lord S,Greenbaum CJ.Changing the course of disease in type1 diabetes.In:Feingold KR,Anawalt B,Blackman MR,eds.Endotext[Internet].MDText.com;January 6,2022. https://www.ncbi.nlm.nih.gov/books/NBK326738/

Resources and Societies
Resource

Resource Address
American Diabetes Association®. Summary of the American Diabetes Association® Type 1 Diabetes Screening & Awareness Roundtable. December 15,2023. https://diabetes.org/sites/default/files/2024-04/ADA-T1D-Screening-and-Awareness-Roundtable-Report.pdf
ASK(Autoimmunity Screening for Kids).T1D screening program. https://www.askhealth.org/
Breakthrough T1D.Enrolling in Clinical Trials. https://www.breakthrought1d.org/clinical-trials/
Breakthrough T1D.Breakthrough T1D Early detection. https://www.breakthrought1d.org/early-detection/
CASCADE Research Study.Type 1 diabetes and celiac disease screening for children in the state of Washington. https://cascadekids.org/
Sanford Research.PLEDGE Pediatric Screening Program. https://research.sanfordhealth.org/fields-of-research/diabetes/pledge
Type 1 Diabetes TrialNet.For Healthcare Providers:TrialNet Recommendations for Clinicians. https://www.trialnet.org/healthcare-providers
Type 1 Diabetes TrialNet.Resources for T1D screening& national T1D screening program. https://www.trialnet.org/
University of Colorado-Barbara Davis Center for Diabetes.Ask the experts for early T1D answers and guidance. https://www.asktheexperts.org/

All URLs accessed June 24, 2024