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## Summary

For the full US Prescribing Information, [click here.](https://www.epidiolex.com/PI?_gl=1*1a9ql0o*_gcl_au*NjA3MzM1ODg1LjE3NjQxMTUxOTA.)

For individuals living with hard-to-treat epilepsy, patients may be on multiple medications to help manage their seizures. In this episode, epilepsy experts Ann Hyslop Segeren, MD, and David Burdette, MD, continue their conversation about an antiseizure medication (ASM) for the management of seizures associated with treatment-resistant epilepsy. They discuss consensus-driven practices for concomitant use with other ASMs, including how and when to monitor for adverse events, and what to consider when tailoring doses while initiating concomitant treatments.

The basis of this series is a publication in the journal _Epilepsia Open_. This podcast is sponsored by Jazz Pharmaceuticals and is for US prescribers only. It is intended for informational purposes only and is not a substitute for clinical knowledge or professional judgment. Never disregard professional medical advice or delay in seeking it because of something you have read or heard on this podcast. Podcast presenters are paid consultants for Jazz Pharmaceuticals. There are no certified continued medical education credits approved for the podcast. ©2026 Jazz Pharmaceuticals plc or its subsidiaries. All rights reserved. US-EPX-2500226

**_David Burdette, MD, FACNS_**

_Section Chief, Epilepsy, Spectrum Health Medical Group_

David Burdette, MD, is board certified in neurology, epilepsy and clinical neurophysiology. Dr. Burdette serves as Section Chief, Epilepsy, Spectrum Health Medical Group. He earned his medical degree from Boston University School of Medicine and completed his neurology residency at Boston University Hospitals. Dr. Burdette completed clinical neurophysiology and epilepsy fellowships at University of Michigan Medical Center in Ann Arbor.

**_Ann Hyslop Segeren, MD_**

_Pediatric Neurologist and Clinical Associate Professor, Stanford Medicine Children’s Health_

Ann Hyslop Segeren, MD, is a board-certified pediatric neurologist. Dr. Hyslop Segeren graduated from the University of Texas Medical School at Houston, completed her pediatrics residency at The Mount Sinai Hospital in New York City, and did her neurology residency at the University of Washington and Seattle Children’s Hospital in Washington state. She completed a two-year clinical neurophysiology fellowship at Nicklaus Children’s Hospital with a focus on surgical epilepsy.