Figure 1

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A 25-year-old presents to the dermatologist with six months of spontaneous, recurrent, remitting, erythematous, edematous, and very pruritic plaques that occur anywhere on the body. The lesions are migratory in nature, last no longer than 24-48 hours, and do not leave any marks following disappearance. The patient has no chronic medical problems. They are experiencing intractable itching, which persists despite taking maximal doses of oral antihistamines every day for several months.

Which of the following is a rare adverse effect of the only FDA-approved biologic medication used to treat the underlying condition? Select an option to see full answer details. Image credit: @snelj23

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