Figure 1

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• Quick Quiz

What IHC finding is concerning for the systemic cutaneous variant of this neoplasm?

A 60-year-old cis woman presents to her dermatologist with a progressively enlarging ulcerating and scaly pink to erythematous plaque on the posterolateral neck. This lesion has persisted for years.

Biopsy reveals sheets of large atypical CD30-positive T lymphocytes.

What characteristic immunohistochemical (IHC) finding is concerning for the systemic rather than primary cutaneous variant of this neoplasm? Select an option to see full answer details. Image credit: @G3KR

• Bcl-2

• Beta-F1

• MPO

• ALK

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