Figure 1

Quick Quiz

An autoantibody associated with papules, ulcerations on the knuckles targets which of the following enzymes?

A 45-year-old presents to the dermatologist with several months of itchy scaly pink papules and ulcerations on the knuckles of both hands. The patient also has progressive shortness of breath, and dyspnea on exertion but denies any associated muscle weakness.

The autoantibody most associated with this clinical finding targets which of the following enzymes?

Image credit: @rdasgupta