Altered Mental Status | Figure 1
petrilloanthony
Emergency Medicine Resident
Altered Mental Status
The patient is a 60 y/o F with no reported past medical history who presented to the emergency department obtunded after being last seen normal by family about 24 hours prior. She was febrile and tachycardic (consistent with SIRS).
Diagnosis added by author
Bacterial meningitis
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I was participating on another post and this topic came up, luckily enough, I saw this patient this week in the clinic, so I wanted to bring this case with some valuable learning points, I think....
33F born in India but immigrated to Canada in 2014. Last year had a miscarriage. PMHx significant for Epilepsy, on Carbamazepine 300mg at night time for many years, has been seizure free since 2020. At that time (2020) she had 2 GTCs in a context of sleep deprivation (studying for her MSc exams) and missing medication for 2 days. Prior to this, when she was growing up and up to highschool, she would have numbness and clusiness on left arm (always left) followed by staring off episodes that lasted for a few seconds. No automatisms, these were happening once every 3-6 months. So far, so good, right? Well, now she is 5 weeks pregnant. She has a new PCP and they referred her right away to Neurology due to last failed pregnancy and on Carbamazepine. MRI is shown, please forgive my pulse I'm clearly not a good drawer, but I wanted to highlight the problem, as it is subtle. Back home, they did workup years ago and told her she had Neurocysticercosis, and seizures as a consequence of that "scar in the brain". When she came to Canada, she was referred to a local Neurologist who tried to switch her to Keppra, but she developed dizziness and foggy mind, hence, she advocated herself to continue on Carbamazepine until today. What would be your next steps considering:
- She is pregnant now (G2A1), early, what is the teratogenic risk? if any?
- Would you consider switching her to another medication? why? which one?
- Would you order more tests?
On the pictures, you can see the bubble graph with the % of teratogenicity with different anti seizure meds in the bubble graphic. As you can see, CBZ is not the safest option, the risk is moderate (4-6%). You can see on the blue circle graph better options available with lesser risk, however one could argue she has been seizure free, and now she is pregnant, hence we need to avoid a GTC at all costs as this can be detrimental to the fetus, especially this early in pregnancy. Moreover, class switch while pregnant is not something we would advocate (unless extremely necessary), but within class, we would consider doing an overnight switch, as an outpatient (for example, CBZ to Oxcarbazepine, in this case). Oxcarbazepine has a better teratogenic profile than CBZ.
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