right sided view of an adult human brain post autopsy. Arrow | Figure 1

JLpath

Pathologists' Assistant

Right Sided View of an Adult Human Brain Post Autopsy

Right sided view of an adult human brain post autopsy. Arrow points to the cerebellum.

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In people with mild cognitive impairment (MCI), does using a 18F PET scan with florbetapir predict the progression to Alzheimer's disease dementia (ADD) and other dementias? Cochrane Review; 3 studies (453 participants with MCI). Key findings: At follow-up of 1.6 years, the scan correctly classified 89% of the participants who progressed to ADD but only 58% of the participants who did not progress to ADD. This means that in a group of 100 people with MCI, 15% of whom will develop ADD, we would expect 13 of 15 people to have a positive result and the other 2 participants to be falsely negative. Also 49 people who will not develop ADD would have a negative result, but 36 people who will not develop ADD would have a positive result (false positives).
In a study that followed up people for 3 years, the scan correctly classified 67% of people who progressed to ADD and 71% who did not progress to ADD. This means in a group of 100 people with MCI, 19 of whom will develop ADD, we would expect 13 people to have a positive result of the scan and 6 people to have a falsely negative result. Also 58 of 81 participants who will not progress to ADD would have a negative result, but 23 people who will not develop ADD would have a positive result (false positives).
That 18F-florbetapir PET scans cannot be recommended for routine clinical use based on the currently available data.

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