PET and CT imaging are often used to ascertain changes in tu | Figure 1

PET and CT Imaging for Tumor Response Evaluation

PET and CT imaging are often used to ascertain changes in tumors. 1) PET scans of diffuse large B-cell lymphoma, before and after 3 cycles of chemo. 2) Axial and coronal F-fluorothymidine (FLT) PET scans of breast cancer before (A) and after (B) 1 cycle of chemo. Arrows indicate masses that changed size. 3) CT and PET/CT fused images of the same patient.

Analogs of thymidine (such as FLT) are used to image cell proliferation because thymidine is used during DNA synthesis. What are the pros and cons of using FLT-PET scans to assess tumor treatment response?

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59 y/o male with h/o Large B cell lymphoma, post REPOCH chemo, and splenectomy, pancreatectomy for extranodal dz. Liver lesions present before and after therapy. LDH normal. MRI post contrast, Fused PET/CT and ultrasound.....Diagnosis?

Elderly female. Thigh lesion resected and positive for B cell lymphoma. Staging PET/CT

99mTc-hdp bone scan vs FDG PET/CT scan in a 52 y/o female with known her2 positive breast cancer. Image 1 is bone scan. Image 2 is pet scan. The view is of the lumbo-sacral region. Here we see a small left sacral lesion consistent with osteoblastic metastasis. A good example of the growing superiority of FDG PET/CT in the detection of Osseous bone metastasis compared to bone scan. PET imaging has higher specificity and accuracy compared to a bone scan. They are both utilized in the detection of bone metastases and the response to treatment.

Previous case that I never added CT results to. Most recent PET scans show marked improvement and the patient is now done with chemotherapy. Follicular dendritic cell histocytic sarcoma.

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