rpr and tpha positive. HIV negative. Sharing is caring! #lov | Figure 1

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rpr and tpha positive. HIV negative. Sharing is caring! #lovederm

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A 23‐year‐old man presented with a 2‐month history of recurrent fever and progressing skin ulcers with eschars on his face, trunk and extremities (a, b). Treponemal serology test was positive and immunohistochemistry of his skin biopsy showed numerous spirochetes (c, arrows). Additional results confirmed that he was infected with HIV, with a decreased CD4+ T‐cell count. A diagnosis of malignant syphilis associated with HIV infection was finally made. Malignant syphilis is an uncommon manifestation of secondary syphilis, characterized by generalized ulcerative skin lesions with prodromal symptoms. Generally, it occurs in immunosuppressed individuals, especially in HIV‐infected patients. Malignant syphilis may be the initial presentation of underlying HIV infection. The patient was treated with doxycycline 100 mg twice daily for 14 days as he was allergic to penicillin. The therapy resulted in rapid regression of the skin lesions (d), and antiretroviral therapy was initiated.

condylomata lata in syfilis stadium 2, went away quite quickly after penidural 2,4 million IE](https://app.figure1.com/case-detail/0860c119-791e-4ea2-bd12-34480ba61197)

No c/o itching, + pain, + RPR & + syphilis titer. Rash starts at #Umbilicus & wraps to buttocks. Syphilis rash?](https://app.figure1.com/case-detail/149d384e-0675-4640-b8c6-74751a48c6e1)

2 week hx of lesion. VDRL and TPHA negative. Bisexual male. 42 year old. no condom use.](https://app.figure1.com/case-detail/17dc4ce4-addc-46ad-bda8-c842a4f45cc0)

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