Osteolysis in Total Ankle Replacement | Figure 1

Osteolysis in Total Ankle Replacement

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Key Points:

Aseptic loosening of total ankle replacement remains enigmatic regarding its underlying mechanisms.
Although great scientific efforts have been made to explain the mechanisms, it remains poorly understood, complex and multifactorial.
Many factors, including age, body weight, activity lesions, implant designs, fixation methods, material properties, immunologic responses, and biomechanical adaptations to total ankle replacement all contribute to the development of perioprosthetic osteolysis.

Summary:

Aseptic loosening of implants remains the most common reason for revision surgery for hip, knee, or ankle prostheses. Although a great scientific effort has been made to explain the underlying mechanisms it remains poorly understood, complex, and multifactorial. Many factors, including age, body weight, activity lesions, implant design, fixation methods, material properties, immunologic responses, and biomechanical adaptations to TAR all contribute to the development of periprosthetic osteolysis.

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