CHAMPION-AF: Left Atrial Appendage Closure Matches Blood Thi | Figure 1

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CHAMPION-AF: Left Atrial Appendage Closure Matches Blood Thinners in AFib

Post in Interventional Cardiology, Internal Medicine, Electrophysiology, Neurology, Cardiology, Stroke Neurology, Hematology, Cardiac & Thoracic Surgery

The CHAMPION-AF trial found that left atrial appendage closure with the WATCHMAN FLX device was noninferior to NOACs for the composite endpoint of stroke, cardiovascular death, and systemic embolism over three years in patients with non-valvular AFib eligible for long-term anticoagulation. While ischemic stroke rates were slightly higher with device therapy, LAA closure was associated with significantly fewer major bleeding events and demonstrated superiority for net clinical benefit, suggesting it may represent a reasonable alternative to anticoagulation within a shared decision-making framework.

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