Name the problem: Case 19. 59 y/o female with primary CNS B- | Figure 1

Case 19

59 y/o female with primary CNS B-cell lymphoma and known left temporal/basal ganglia mass. She is s/p 6 cycles of high dose methotrexate and rituximab, as well as temozolomide with progression of disease. She underwent whole brain irradiation and was subsequently started on TEDDI-R therapy. Within a month, she developed nodular pneumonia. She developed increasing somnolence and MRI was obtained that showed the following. There should be one, at most two, top etiologies in your differential based on the above history. What are they? And why?

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