New Engineered T-Cell Immunotherapy Could Minimize GVHD Afte | Figure 1

New Engineered T-Cell Immunotherapy Could Minimize GVHD After Allogeneic HSCT

Post in Hemophilia & Bleeding Disorder, Pediatric Hematology-Oncology, Research, Hematologic Oncology, Hematology, Hematopathology

New From Cancer Nursing Today

Orca-Q, an investigational precision engineered allogeneic T-cell therapy, demonstrated promising safety and efficacy in a phase 1 study of patients with high-risk hematologic malignancies undergoing allogeneic stem cell transplantation. The phase 1 study, presented at the 67th American Society of Hematology Annual Meeting and Exposition, showed that all patients achieved neutrophil engraftment by day 20 with low rates of acute and chronic graft-versus-host disease. One- and two-year overall survival rates were 90% and 86% with low nonrelapse mortality. Patients treated without immunosuppression experienced faster immune recovery and fewer infections, suggesting Orca-Q may help control GVHD while supporting immune reconstitution.

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