CincyKidsRad

Cincinnati Children's Radiology

Septooptic dysplasia

Coronal T2 (image 1), axial T2 (image 2), and axial FIESTA (image 3) MRI show multiple findings indicative of septo-optic dysplasia: the optic chiasm (arrow) is undersized, the septum pellucidum is absent, and the optic nerves (arrowhead) are slightly hypoplastic. Septo-optic dysplasia, which may be linked to maternal diabetes, drug and alcohol use, or cytomegalovirus infection, is considered part of the holoprosencephaly spectrum and can be associated with other neural migrational disorders.