Figure 1

Quick Quiz

A 65-year-old female presents to a physician for the first time in 25 years with a history of weight loss and weakness. On examination, she is hypertensive and her extremities demonstrate pitting edema. Urinalysis shows proteinuria. An abdominal fat pad tissue biopsy reveals deposits of amyloid and further immunochemical staining demonstrates serum amyloid A (SAA) proteins. Which of the following conditions is most likely to be part of this patient’s past medical history? Image credit: @ReginaldoCastro.