Septo-optic dysplasia | Figure 1

Septo-optic dysplasia

Coronal (image 1) and sagittal (image 2) T1-weighted MRI image of the brain shows absence of the septum pellucidum, hypoplasia of the optic nerves (arrowheads, image 1), and hypoplasia of the pituitary (arrow, image 2). Septo-optic dysplasia can be associated with polymicrogyria, schizencephaly, and other midline malformations. Ocular anomalies such as coloboma or microphthalmia may be present.

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Coronal (image 1) and axial (image 2) T2-W images show a mass (arrow) arising from the optic chiasm. Optic pathway gliomas are more common in children and are associated with neurofibromatosis type 1. The tumor can affect any portion of the optic pathway. Approximately a third of optic pathway gliomas primarily involve the optic chiasm.
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Coronal T2 (image 1), axial T2 (image 2), and axial FIESTA (image 3) MRI show multiple findings indicative of septo-optic dysplasia: the optic chiasm (arrow) is undersized, the septum pellucidum is absent, and the optic nerves (arrowhead) are slightly hypoplastic. Septo-optic dysplasia, which may be linked to maternal diabetes, drug and alcohol use, or cytomegalovirus infection, is considered part of the holoprosencephaly spectrum and can be associated with other neural migrational disorders.](https://app.figure1.com/case-detail/2332e537-4821-4017-8491-403bc40f5f7e)

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