0ab0fbe6 03ce 43f7 91a7 2e3ceb598bde

2MinuteMedicine


  1. No significant difference in severe urinary tract infections was observed between patients starting SGLT-2 inhibitors for type 2 diabetes, compared to DPP-4 inhibitors or GLP-1 agonists.

  2. These findings contrast with the significantly higher rates of urinary tract infections observed in patients taking SGLT-2 inhibitors compared to those taking placebo in randomized trials.

Evidence Rating Level: 2 (Good)

Click to read the study summary at 2 Minute Medicine


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April 6, 2020

In a paper published in the preprint journal medRxiv, researchers in Wuhan, China analyzed medical records of patients hospitalized with confirmed SARS-CoV-2 infection. They separated patients with both covid-19 and high blood pressure (hypertension) into two groups: patients who had been prescribed the antihypertensives “ACE inhibitors” and “ARBs,” and patients who had not been prescribed either of these medications. The question: do ACE inhibitors or ARBs have any effect, good or bad, on covid-19 infection? As previously covered in Brief19, experts have debated the use of these medications.

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