T2 (image 1) and T1-hepatocyte phase post-contrast MRI of th | Figure 1

CincyKidsRad

Cincinnati Children's Radiology

T2 (image 1) and T1-hepatocyte phase post-contrast MRI of the liver in an adolescent with autoimmune hepatitis shows a markedly abnormal appearance of the liver. On the T2 image, there are lace-like areas of increased signal.

On the post-contrast image, the liver should have a homogeneous bright appearance. Instead, all of the dark areas are abnormal. The pattern is typical of hepatic fibrosis. Autoimmune hepatitis is often a diagnosis of exclusion. Patients have elevated serum alanine aminotransferase and IgG.

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Axial T2-weighted (image 1), T1-weighted (image 2), and postcontrast hepatobiliary phase (image 3) MR images of the liver in a patient with Alagille syndrome show a poorly defined area of signal abnormality (arrow) within the central portion of the liver, representing nodular regenerative hyperplasia. This pattern is common in patients with Alagille syndrome and other cholangiopathic disorders.

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