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Chagas'-disease vector, Triatomas infestans.

Parasite-infections

trypanosoma

A new complex presented encouraging results against the parasite that causes Chagas disease, known scientifically as Trypanosoma cruzi. This was the discovery of a group of researchers from the Center for Research on Inflammatory Diseases (Crid), published in the journal Dalton Transactions, through a partnership between the Federal University of the Triângulo Mineiro (UFTM) and the Freie Universität Berlin, Germany.

The complex consists of gold and an organic compound, thiosemicarbazone. This second molecule, when in contact with the parasite Trypanosoma cruzi, is responsible for crossing the cell membrane and acting directly on the more resistant form in the amastigote.

According to Carla Lopes, gold is a metal that can play the role of de-structuring the Trypanosoma cruzi DNA or act elsewhere in the metabolic pathway. The idea is that the metal complex acts on multiple targets against it. However, its mechanism of action still needs to be better studied.

In light of other analyses of the study, it is known that small amounts of the compound need be used to kill the parasite. In addition, it does not lose its properties when in solid state. This allows it to be transported without the need for cooling, which is important, considering that populations affected by Chagas disease are not always in easily accessible places.

Source: Dalton Transactions.

Tripanozoma cruzi

Trypomastigote found in human blood This is the infective form for the vector. If the triatomine bites and it's this parasite in the blood, the triatomine immediately becomes vector of the disease (Chagas disease). It can invade tissues like muscles, nerves and lymph nodes.

Not a patient, but I work in the Peruvian rainforest and have seen these around a few times. They seem to hover and fly in an 'air-hopping' fashion. Locals report people bitten by these baddies usually develop a small subcutaneous worm that they call 'Tupe' and I get to treat as a myasis. No name given for this guy. If anyone has seen it before, I'd love some insight. Thanks!

A 52-year-old man presented with a 20-minute history of chest pain radiating to the left shoulder and neck, associated with dyspnea and diaphoresis. He had a history of hypertension, long-term smoking, and a sedentary lifestyle. On physical examination, bibasilar crackles were noted on lung auscultation. An electrocardiogram (ECG) was performed in the primary care setting, and the patient was promptly referred to the emergency department.

A 28-year-old woman presented with a 3-day history of intense pruritus over the lower back. She reported no recent travel or exposure to new environments. She cares for a small kennel with approximately eight dogs rescued from the streets. Physical examination revealed multiple small vesicles, some clustered and others scattered, predominantly involving the lumbar region and the left gluteal area.

A 4-month-old male infant presented with skin lesions localized to the chin for the past 3 days. Physical examination revealed multiple small pustules with surrounding inflammatory signs on the chin, along with a few scattered papules on the chest.

Patient in late teens presenting after a collapse, no chest pain, no previous cardiac history, no history of sudden death in family, are there any features in this ekg that would warrant further work-up or is this just a pediatric ekg?